The Alpha Tubulin Acetyltransferase atat-2 Genetically Interacts With klp-4 in C. elegans

Document Type

Article

Publication Date

12-31-2025

Abstract

Microtubules dynamics are in part regulated by post-translational modification, including acetylation. Little is known about the relationship between microtubule acetylation status and how this affects kinesin function, especially in vivo. Using a series of aldicarb sensitivity assays in C. elegans where we combined pharmacological manipulation of microtubule dynamics with genetic approaches, we demonstrate a specific genetic interaction between the alpha tubulin acetyltransferase atat-2 and the kinesin motor klp-4. Our work highlights interactions between kinesin activity and the tubulin code in vivo and lays the foundation of future work on these two parallel, yet related processes in cells.

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Originally published in MicroPublication Biology

Publication Title

MicroPublication Biology

DOI

10.17912/micropub.biology.001536

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