A Source of Human Ovarian Cortical Tissue from Sex Assignment Surgery Cryopreservation of ovarian cortical tissue is a novel technique for the preservation of primordial follicles with the aim to restore fertility in young female cancer patients after chemotherapy. Grafting of cryopreserved ovarian cortical tissue has attracted much interest as a means for the restoration of fertility. There is a scarce availability of donated cortical ovarian tissue that limits the research on follicular growth after grafting. A new resource of donors can be found in young female-to-male transsexual donors who have been on androgen therapy for prolonged periods of time. This paper examines the process of patients on androgen therapy for prolonged periods of time and the effects it may or may not have on the primordial follicle pool. Finally, a thorough examination will look at the possibility of using ovaries from individuals who undergo sex-reversal operations as an excellent source of tissue for research and maybe even for oocyte donation in the future.
Nguyen, Quynh T.
"A Source of Human Ovarian Cortical Tissue from Sex Assignment Surgery,"
Rollins Undergraduate Research Journal: Vol. 5
, Article 3.
Available at: http://scholarship.rollins.edu/rurj/vol5/iss1/3